ExpreS2ion Biotechnologies is a world leading contract research organisation (CRO) within production in Drosophila Schneider-2 (S2) cells.

For 15 years we have developed, and actively used our proprietary and complete S2 recombinant protein technology ExpreS2.

We have in-depth practical experience with this non-viral Drosophila S2 expression technology for the production of recombinant proteins for research, preclinical development and for use in clinical trials.

Our solutions:

Products

    • Transfection reagent
    • Licenses: Research, Commercial or Manufacturing
    • Protein Expression Kits

Services

    • Production of proteins for R&D
    • Process development for clinical material manufacturing
    • Establishment of research cell banks (RCB)
Customers and collaborating partners

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About

ExpreS2ion Biotechnologies is a world leading CRO biotech company

Our company has a proprietary and complete S2 recombinant protein technology base – ExpreS2, which was developed over ten years at Pharmexa A/S. We have in-depth practical experience with the non-viral Drosophila S2 expression technology for the production of recombinant proteins for preclinical development and for use in clinical trials.

Contribution to Malaria Vaccines/Research

By leveraging our ability to express malaria parasite proteins with ExpreS2 a cGMP-compatible system, we have enabled progress of malaria vaccine candidates into clinical research. ExpreS2ion Biotechnologies is working with top academic teams to advance vaccines directed at different malaria stages of infection: blood stage malaria and pregnancy malaria.

Solutions

Services, Custom Proteins

“Challenging proteins made easy”

The ExpreS2 system, based on Drosophila S2 cell expression can solve your “protein dead-ends” by providing an alternative, cGMP-compatible expression system.
When to choose the S2 expression system:

  • Secreted or secretable proteins
  • Low/non-expressing proteins in HEK293 or BEVS
  • Issues with protein cleavage during production
  • Heterodimers or further multimeric proteins
  • If variable glycosylation is an issue
  • If you need a cGMP-compatible system

ExpreS2ion Biotechnologies specializes in establishment of high-producing cell lines together with upstream process development and working with customers to solve technical problems in molecular biology, protein expression or other issues relating to S2 cells. S2 related reagents are also available.

NEWS / EVENTS

Latest news

August 2014 : ExpreS2ion® Biotechnologies today announces the publication of the article: "Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies" in the high impact scientific journal Nature, with teams at the University of Oxford. Enabled by the ExpreS2 technology platform, the study provides a significant step in understanding the binding of the malaria parasite to blood cells. Read the PR

August 2014 : "Improving yields in a novel Drosophila S2 Expression System": Wian de Jongh will present at the 6th Annual Bioprocessing summit in Boston, USA Continue reading

May 2014 : PEGS 2014, Boston, USA - ExpreS2ion’s CSO Wian de Jongh is presenting a poster entitled “Expression of Difficult to Express Proteins using the Drosophila S2-based ExpreS2 system”

Publications
  • "Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies" enabled by the ExpreS2 technology platform: Nature (17 August 2014), doi:10.1038/nature13715 Read the abstract here

  • The external domain of rat ErbB-2 conjugated with a tetanus toxin Th-cell epitope were produced in Drosophila melanogaster S2 insect cell cultures, in the recent publication: Vaccine. 2014 Feb 12;32(8):1012-8. doi: 10.1016/j.vaccine.2013.10.077. Epub 2013 Nov 11

  • Comparison of prophylactic and therapeutic immunisation with an ErbB-2 (HER2) fusion protein and immunoglobulin V-gene repertoire analysis in a transgenic mouse model of spontaneous breast cancer. Mukhopadhyay A, Dyring C, Stott DI. Read the abstract here

  • ExpreS2ion Biotechnologies: Agern Allé 1, DK-2970 Horsholm, Denmark E-mail: info@expres2ionbio.com Phone: +45 4166 6121